The Conti Laboratory studies the mechanisms of alcohol action in the traumatically-injured brain. Using rodent models, experiments are designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol. Additional studies are aimed to examine ethanol-related behaviors, such as binge consumption and withdrawal. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in a model of Fetal Alcohol Syndrome and mediate ethanol-induced neuroplasticity. Together, these studies provide the basis for the identification of protein targets of alcohol which can be used to develop interventions for the alcohol-damaged brain.