The Conti Laboratory studies the mechanisms of opioid action in the traumatically-injured brain. We use animal models of TBI to identify how combined exposure to brain injury and morphine affect pain behavior and targets of opioid action in the brain - opioid receptor signaling and neuroinflammation (immune system activation). These projects address the critical need for an understanding of the mechanisms by which opioids administered post-TBI might alter later pain states and uphold the mission for VA patient care and rehabilitation to improve/expand the effective treatment options for individuals suffering from TBI.